Vaccine and Drugs for COVID-19 Coronavirus / companies across the world are developing Vaccine for Coronavirus that are in various stages
Scientists in Israel likely to announce the development of a coronavirus vaccine
Scientists in Israel are expected to announce in the coming days that they have completed development of a vaccine for the new coronavirus COVID-19,
Quoting medical sources, Israeli daily Ha'aretz, reported on 12th March 2020 that scientists at Israel's Institute for Biological Research, supervised by the Prime Minister's office, have recently had a significant breakthrough in understanding the biological mechanism and qualities of the virus, better diagnostic capability, production of antibodies for those who already have the virus and development of a vaccine.
Following companies across the world are developing Vaccine for Coronavirus that are in various stages
1. Inovio Pharmaceuticals and Beijing Advaccine Biotechnology
Inovio aims to produce one million doses of the vaccine INO-4800 by the end of 2020 to perform additional clinical trials or emergency use.
Vaccine - INO-4800
2. Moderna and Vaccine Research Center
Unit of the National Institute of Allergy and Infectious Diseases (NIAID) have collaborated to develop a vaccine for coronavirus.
phase one clinical trial scheduled to start in April 2020
Vaccine - mRNA-1273
3. MIGAL Research Institute of Israel
The Institute has genetically modified the vaccine to treat Covid-19 and will be available in the oral form.
Vaccine: Avian Coronavirus Infectious Bronchitis Virus (IBV) vaccine
4. Tonix Pharmaceuticals with Southern Research
TNX 1800 is designed to express a protein derived from the virus that causes the coronavirus infection
5. Clover Biopharmaceuticals of China
The company is developing a vaccine based on the trimeric S protein (S-Trimer) of the Covid-19 coronavirus, which is responsible for binding with the host cell and causing a viral infection
6. Vaxart, United States
Vaxart is developing an oral recombinant vaccine in tablet formulation using its proprietary oral vaccine platform.
7. Applied DNA Sciences
Applied DNA Sciences’ subsidiary LineaRx and Takis Biotech formed a joint venture on 07 February to develop a linear DNA vaccine as a treatment for coronavirus.
The joint venture will use Polymerase Chain Reaction (PCR)-based DNA manufacturing technology to develop the vaccine.
Generex has announced that it is developing a COVID-19 vaccine the company will utilise its Ii-Key immune system activation technology to produce a Covid-19 peptide for human clinical trials
9. Tulane University
Tulane University has launched a research programme to identify a potential medicine for coronavirus in the form of a vaccine
10. ImmunoPrecise Antibodies
ImmunoPrecise Antibodies has launched a vaccine and therapeutic antibody programme to develop a vaccine as well as antibodies against Covid-19
11. Serum Institute of India
Serum Institute of India (SII) is collaborating with Codagenix, a US-based biopharmaceutical company, to develop a coronavirus cure using a vaccine strain similar to the original virus. it expects to be ready with a vaccine against the novel coronavirus (COVID-19) by early 2022.
12. Zydus Cadila
Zydus Cadila, announced that it has initiated an accelerated research programme with multiple teams in India and Europe developing a vaccine for the novel coronavirus, 2019-nCoV (COVID-19) based on two approaches. The first approach deals with the development of a DNA vaccine against the major viral membrane protein responsible for the cell entry of the novel coronavirus, now called COVID19. The plasmid DNA would be introduced into the host cells, where it would be translated into the viral protein and elicit a strong immune response mediated by the cellular and humoral arms of the human immune system, which play a vital role in protection from disease as well as viral clearance.
13. Vir Biotechnology
Vir Biotechnology, a clinical-stage immunology company, announced on 12 February that it has identified two monoclonal antibodies that can bind to the virus that causes Covid-19. The antibodies target the spike (S) protein of the virus by entering through the cellular receptor ACE2
The novel coronavirus COVID-19 drugs in various stages of development globally as listed below
1. Gilead Sciences
Drug Name: Remdesivir (GS-5734)
According to a report by The New England Journal of Medicine (NEJM), Remdesivir, when administered to a coronavirus COVID-19 patient in the US but yet not have solid data to indicate it can improve clinical outcomes,
2. Biocryst Pharma
Drug Name: Galidesivir (BCX4430)
Is an antiviral drug
Pfizer announced that it has identified certain under development antiviral compounds that may be effective in treating coronavirus.
4. Mateon Therapeutics
Company has formed a new Division to develop a multi-modal approach to treating the COVID-19 and future emergent zoonotic outbreaks